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When Bcl-two was overexpressed, it heterodimerized with Bax and death was repressed, As a result the ratio of Bcl-2 to Bax is essential in pinpointing susceptibility to apoptosis [42]. Within this study, our results unveiled that Bcl-two expression was down-regulated remarkably when Bax expression plus the active type of caspase-3 were up-regulated